Released on: August 15, 2008, 8:32 am

Press Release Author: The Scott Partnership

Industry:

Press Release Summary: SAN JOSE, Calif. (August 15, 2008) - Thermo Fisher Scientific
Inc., the world leader in serving science, today announced that Princeton University
is utilizing the newly launched MALDI LTQ Orbitrap XL mass spectrometer for research
on virus-host protein interactions in the laboratory of Ileana Cristea, Ph.D. Dr.
Cristea\'s cutting-edge work on chromatin and its modulation by viruses promises to
further scientists\' understanding about how viruses manipulate their host to their
advantage. The laboratory employs a multidisciplinary approach, incorporating
methodologies from modern proteomics, biochemistry, molecular biology and virology.
The research, while preliminary, holds implications for improved therapies for the
treatment of viral infections, from the common cold to HIV.


Press Release Body: FOR IMMEDIATE RELEASE
Mass Spectrometry
Media Contact Information:
Name: Laura Browne/Charlotte Culley
Phone: +44 1477 539539
Email: thermo@scottpr.com
Website: www.scottpr.com

Secondary Contact Information:
Stephanie Kubina
+1 (408) 965-6022
stephanie.kubina@thermofisher.com

Princeton University Selects Thermo Scientific MALDI LTQ Orbitrap Mass Spectrometer
to Enable Proteomics and Genomics Research on Viruses

SAN JOSE, Calif. (August 15, 2008) - Thermo Fisher Scientific Inc., the world leader
in serving science, today announced that Princeton University is utilizing the newly
launched MALDI LTQ Orbitrap XL mass spectrometer for research on virus-host protein
interactions in the laboratory of Ileana Cristea, Ph.D. Dr. Cristea\'s cutting-edge
work on chromatin and its modulation by viruses promises to further scientists\'
understanding about how viruses manipulate their host to their advantage. The
laboratory employs a multidisciplinary approach, incorporating methodologies from
modern proteomics, biochemistry, molecular biology and virology. The research, while
preliminary, holds implications for improved therapies for the treatment of viral
infections, from the common cold to HIV.

Because the samples required for the studies are difficult to obtain and the
elements of interest are frequently present at very low levels, Dr. Cristea began
exploring the benefits of combining MALDI with state-of-the-art mass spectrometry
(MS) instrumentation. Interested in novel MS developments, she believed there would
be significant benefit with the integration of the Thermo Scientific LTQ Orbitrap
with a MALDI interface.

\"I am quite impressed that I have in my laboratory the first configuration of its
kind in the MALDI LTQ Orbitrap XL,\" said Dr. Cristea, Assistant Professor with
Princeton University\'s Department of Molecular Biology. \"Its performance has already
proven to be terrific. This instrument combines the robustness and high throughput
capabilities of MALDI with the sensitivity of the linear trap and the high mass
accuracy and resolution of the Orbitrap.
The MALDI LTQ Orbitrap XL is perfectly suited for characterizing protein complexes.
After the initial MS and MS/MS analyses and identifications, the samples can be
preserved on the MALDI target to pursue new interesting directions revealed by the
first analyses.\"

The MALDI option is available for both the LTQ Orbitrap Discovery and LTQ Orbitrap
XL platforms. The addition of the new MALDI source on the LTQ Orbitrap is suited for
proteomics and metabolism applications, making it easier to analyze biological and
polymer samples without extensive sample preparation. Other applications include
high-throughput in-gel digest, de novo sequencing, quantitation based on isobaric
labeling strategies (TMT Tags, iTRAQ), tissue imaging and small molecule analysis.

For more information on the new Thermo Scientific MALDI LTQ Orbitrap mass
spectrometer, please call +1 800-532-4752, email analyze@thermofisher.com or visit
www.thermo.com/orbitrap.

Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving
science.

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science,
enabling our customers to make the world healthier, cleaner and safer. With annual
revenues of $10 billion, we have more than 30,000 employees and serve over 350,000
customers within pharmaceutical and biotech companies, hospitals and clinical
diagnostic labs, universities, research institutions and government agencies, as
well as environmental and industrial process control settings. Serving customers
through two premier brands, Thermo Scientific and Fisher Scientific, we help solve
analytical challenges from routine testing to complex research and discovery. Thermo
Scientific offers customers a complete range of high-end analytical instruments as
well as laboratory equipment, software, services, consumables and reagents to enable
integrated laboratory workflow solutions. Fisher Scientific provides a complete
portfolio of laboratory equipment, chemicals, supplies and services used in
healthcare, scientific research, safety and education. Together, we offer the most
convenient purchasing options to customers and continuously advance our technologies
to accelerate the pace of scientific discovery, enhance value for customers and fuel
growth for shareholders and employees alike. Visit www.thermofisher.com.

For further press information please contact: Laura Browne, The Scott Partnership, 1
Whiteside, Station Road, Holmes Chapel, Cheshire. CW4 8AA United Kingdom Tel: + 44
1477 539539 Fax: +44 1606 1477 539540 E-mail:
thermo@scottpr.com

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Contact Details: Media Contact Information:
Name: Laura Browne/Charlotte Culley
Phone: +44 1477 539539
Email: thermo@scottpr.com
Website: www.scottpr.com

Secondary Contact Information:
Stephanie Kubina
+1 (408) 965-6022
stephanie.kubina@thermofisher.com